Can I use Kadian if I am taking an antidepressant?

If you're on an antidepressant, talk to your doctor before taking the extended-release pain medication Kadian (morphine). It is dangerous to combine Kadian with a certain type of antidepressant known as a monoamine oxidase inhibitor (MAOI). In fact, you should not take Kadian within 14 days of taking an MAOI, because doing so may lead to serious or life-threatening side effects. Examples of MAOIs include the following:
  • phenelzine
  • tranylcypromine
  • isocarboxazid
  • selegiline

In addition, antidepressants such as the following slow the functioning of the nervous system and can increase the risk of serious or potentially life-threatening side effects if taken with Kadian: 

  • amitriptyline
  • amoxapine
  • clomipramine
  • desipramine
  • doxepin
  • imipramine
  • nortriptyline
  • protriptyline
  • trimipramine

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.