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Can I use Fentora if I am taking isocarboxazid (Marplan)?

You can't use Fentora (fentanyl), a medication for treating breakthrough cancer pain, if you take the antidepressant isocarboxazid (Marplan). In fact, you can't start taking Fentora until at least two weeks have passed since your last dose of isocarboxazid. These two drugs are dangerous in combination -- taken at the same time, they put you at high risk for shock, seizure, coma, low blood pressure and a potentially fatal slowdown of breathing.

Work out a plan with your doctor to stop isocarboxazid before starting Fentora and ask about substituting a newer type of antidepressant, such as nefazodone (Serzone), fluvoxamine (Luvox) or fluoxetine (Prozac, Sarafem). Although these types of antidepressants can also interact with Fentora, the risks can usually be lessened when you work closely with your doctor to find the right doses of each.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.