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Can I use Fentora if I take rifampin?

You can take Fentora (fentanyl), a morphine-like drug for breakthrough cancer pain, if you're on the tuberculosis medicine rifampin (Rifadin, Rimactane; in Rifamate and IsonaRif). However, the two drugs do interact. Rifampin makes Fentora less effective, because it speeds up the body's excretion of the pain drug. But with tweaking, your doctor should be able to balance the two medicines so they are both effective.

Once this balance is achieved, it's very important not to stop taking either medicine without consulting with your doctor first. Stopping rifampin while you're still on the same dose of Fentora puts you at risk for serious side effects, including a fatal overdose.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.