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Can I use Fentora if I take phenytoin (Di-Phen, Dilantin, Phenytek)?

You can use Fentora (fentanyl), a medication for treating breakthrough cancer pain, if you take the antiseizure medicine phenytoin (Di-Phen, Dilantin, Phenytek), although the two drugs do interact. Phenytoin makes Fentora less effective in controlling pain, because it speeds up the body's excretion of the pain drug. But with tweaking, your doctor should be able to find the right balance between the two medicines so they are both effective.

Once this balance is achieved, it's very important not to stop taking either medicine without consulting with your doctor first. Stopping phenytoin while you're still on the same dose of Fentora puts you at risk for serious side effects, including a fatal overdose.

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