Can I use Fentora if I take carbamazepine?

You can take Fentora (fentanyl), a morphine-like drug for breakthrough cancer pain, if you use the antiseizure drug carbamazepine (Carbatrol, Epitol, Tegretol), although the two drugs do interact. Carbamazepine makes a standard dose of Fentora less effective in controlling pain, because it speeds up the body's excretion of the pain drug. But your doctor should be able to find the right balance between the two medicines so they are both effective, although it may take some tweaking of doses. Once this balance is achieved, you should not stop taking either medicine without consulting with your doctor first. Going off carbamazepine while you're still taking the same dose of Fentora puts you at risk for serious side effects, including a fatal overdose.

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