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Can I use ConZip if I take an SNRI?

Your doctor will be very careful about prescribing the pain medication ConZip (tramadol) for you if you're taking an antidepressant that's a serotonin and norepinephrine reuptake inhibitor (SNRI) such as venlafaxine (Effexor), desvenlafaxine (Pristiq) and duloxetine (Cymbalta). The combination of ConZip and an SNRI can increase the risk of serious side effects, including seizures and serotonin syndrome, a rare but deadly condition that can occur if levels of the brain chemical serotonin become too high. Symptoms of serotonin syndrome include agitation, hallucinations, coma, rapid heartbeat, dramatic blood-pressure changes, very high fever, coordination problems, twitching, nausea, vomiting and diarrhea.

Also, if you're taking an SNRI to treat depression, be aware that ConZip increases the risk of suicide in people who are already vulnerable to suicidal thoughts or behaviors. Be sure your doctor knows about your depression and how it's being treated before you start to take ConZip.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.