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Can I use Subutex if I am taking methotrexate?

If you are taking methotrexate, talk to your doctor and pharmacist before taking Subutex (buprenorphine), a medicine that helps treat addiction to opioids, including heroin, morphine and other narcotic painkillers. Methotrexate, which suppresses the immune system and is used to treat psoriasis, rheumatoid arthritis and some cancers, may interact with Subutex. That interaction may affect how well one or both of the drugs work and may raise your risk for side effects. Your doctor may need to adjust your dose of one or both medicines and monitor you for side effects.

Methotrexate is one of many drugs that may interact with Subutex. Before starting treatment with Subutex, give your doctor and pharmacist a list of all your other medicines (prescription and nonprescription) and herbal and dietary supplements. Once you're on Subutex, do not take any new drug or supplement without checking with your doctor and pharmacist first.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.