Can I use Nucynta if I am taking migraine medications?

Taking the pain medication Nucynta (tapentadol) along with a migraine medication from the group called triptans can cause a rare but potentially deadly condition called serotonin syndrome. Nucynta is still prescribed for people taking triptans, but you should be aware of the risk. Triptans include: almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet) and zolmitriptan (Zomig). Like Nucynta, these drugs increase your levels of the chemical serotonin. If you take both kinds of medications, it’s possible to end up with a dangerously high amount of the chemical in your system. Symptoms of serotonin syndrome include: agitation, hallucinations, coma, rapid heartbeat, dramatic blood-pressure changes, dangerously elevated body temperature, coordination problems, twitching, nausea, vomiting and diarrhea. Let your doctor know about any migraine medication you take before using Nucynta -- or once you've begun using it.