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Can I use ConZip if I am taking St. John's wort?

Your doctor will be very careful about prescribing the pain medication ConZip (tramadol) if you use the herbal supplement St. John's wort. Research suggests that St. John's wort, which is used to treat depression, can lower ConZip's effectiveness and also put you at risk for serotonin syndrome, a rare but possibly dangerous condition that can occur if levels of the brain chemical serotonin become too high. Symptoms of serotonin syndrome include agitation, hallucinations, coma, rapid heartbeat, dramatic blood-pressure changes, dangerously high fever, coordination problems, twitching, nausea, vomiting and diarrhea. Serotonin syndrome can be fatal.

If you're taking St. John's wort to treat depression, be aware that ConZip increases the risk of suicide in people who are already vulnerable to suicidal thoughts or behaviors. Be sure your doctor knows about your depression and how it's being treated before you start to take ConZip.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.