Can ConZip interact with other medications?

The pain medication ConZip (tramadol) interacts with a number of drugs in ways that increase the risk of seizure and/or the danger of developing serotonin syndrome, a condition that can cause serious side effects and is potentially fatal. Be sure your doctor knows about all drugs and supplements you're taking before you start using ConZip, especially the following:

• ketoconazole (Nizoral), an antifungal
• the antibiotics erythromycin and linezolid
• quinidine, an anti-malaria drug that is also used for certain heart problems
• triptan-type migraine medications such as almotriptan (Axert), sumatriptan (Imitrex) and zolmitriptan (Zomig)
• SNRI (serotonin and norepinephrine reuptake inhibitors) antidepressants, such as venlafaxine (Effexor), desvenlafaxine (Pristiq) and duloxetine (Cymbalta)
• SSRI (serotonin selective reuptake inhibitors) antidepressants, such as fluoxetine (Prozac), citalopram (Celexa), sertraline (Zoloft), paroxetine (Paxil) and escitalopram (Lexapro)
• tricyclic antidepressants, such as amitriptyline (Elavil), amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil) and trimipramine (Surmontil)
• MAOIs (monoamine oxidase inhibitors), such as phenelzine (Nardil), tranylcypromine (Parnate) and isocarboxazid (Marplan)

ConZip also interacts with the antiseizure medication carbamazepine (Carbatrol, Epitol, Equetro, Tegretol) in a way that reduces the amount of pain relief you experience.

Your doctor should monitor you carefully if you take any of the following drugs along with ConZip:

• CNS suppressors. Because ConZip affects the central nervous system, taking it along with drugs that do the same could trigger serious side effects, including coma and death. These drugs include other narcotic pain medications (such as codeine, morphine and oxymorphone), phenothiazines (used to treat psychotic disorders) and some tranquilizers, sedatives, sleeping pills, muscle relaxants and anti-nausea drugs.
• the blood thinner warfarin (Coumadin). In rare cases, the combination has altered warfarin's effect on blood clotting.
• the heart medication digoxin (Digitek, Lanoxicaps, Lanoxin). In rare cases, using ConZip along with digoxin has led to toxic levels of digoxin.