Can I use Actiq if I am taking rifabutin?

You may be able to take Actiq if you're taking rifabutin (Mycobutin), but tell your doctor. Actiq is an opiate lozenge used to treat breakthrough cancer pain. Rifabutin is a medication used to prevent or slow a certain kind of bacterial infection in people who are HIV positive. Using Actiq while taking rifabutin can reduce Actiq’s ability to control your pain. Let your doctor know about every medication you are taking for the treatment of your HIV infection—and any other medical condition—so he or she can adjust your medication regimen if necessary and monitor you more carefully for any adverse reactions to any of your medications.