Can I use Actiq if I am taking MAO inhibitors?

Stacy Wiegman, PharmD

Pharmacy

It is not safe to take Actiq (fentanyl) if you're taking MAO inhibitors. The combination can lead to a fatal reaction. Actiq is a synthetic opiate lozenge used to treat breakthrough cancer pain in patients who are already using opiate-type narcotics for pain. MAO inhibitors are an older class of antidepressants. Taking MAO inhibitors may cause an unpredictable and severe increase in the effects of Actiq. That is why you should stop taking MAO inhibitors at least 14 days before you start taking Actiq.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.