Can I use Actiq if I am taking St. John's Wort?

You may be able to use Actiq if you're using St. John's wort, but talk to your doctor first. Actiq is an opiate used to treat breakthrough cancer pain. St. John's wort is an herbal supplement sometimes used by people with depression. Taking St. John's wort while using Actiq may reduce Actiq's ability to control your pain. Actiq may cause depressive symptoms as a side effect in some people, so it's important that you treat your depression while dealing with cancer pain.