Can I use Actiq if I am taking isocarboxazid?

You should not use Actiq (fentanyl) if you've taken isocarboxazid (Marplan) in the last 14 days. Actiq is a synthetic opiate lozenge used to treat breakthrough cancer pain. Isocarboxazid is an antidepressant that belongs to a class of drugs known as MAO inhibitors. Taking MAO inhibitors while using Actiq can cause fatal drug interactions. Talk to your doctor about other medications that may be safer to take to manage your depression or other behavioral health conditions, while using Actiq.

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