Can I use Actiq if I have a history of kidney disease?

You may be able to take Actiq (fentanyl) if you have a history of kidney disease, but tell your doctor. Actiq is a quick-acting synthetic opiate lozenge used to treat breakthrough cancer pain. Your kidneys break down Actiq and excrete it in urine, so if your kidneys aren't working well, it may affect how your body uses this drug. Tell your doctor about your history of kidney disease and any other medical condition you have, as well as all medications and supplements you take, so that he or she can monitor your carefully when you take Actiq.