Can I use Abstral if I am taking a CYP3A4 inducer?

Taking the cancer pain medication Abstral (fentanyl buccal tablet) with CYP3A4 inducers may reduce your blood level of fentanyl, Abstral's active ingredient. (A CYP3A4 inducer is anything that ramps up a certain enzyme in your body -- one that helps break down this drug.) This could decrease Abstral's effectiveness. Your doctor is likely to closely monitor you for side effects if you're taking Abstral with any of the following:
  • barbiturates
  • carbamazepine
  • efavirenz
  • glucocorticoids
  • modafinil
  • nevirapine
  • oxcarbazepine
  • phenobarbital
  • phenytoin
  • pioglitazone
  • rifabutin
  • rifampin
  • St. John's wort
  • troglitazone (not available in the United States)

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.