Advertisement

Can I use Abstral if I am taking a CYP3A4 inducer?

Taking the cancer pain medication Abstral (fentanyl buccal tablet) with CYP3A4 inducers may reduce your blood level of fentanyl, Abstral's active ingredient. (A CYP3A4 inducer is anything that ramps up a certain enzyme in your body -- one that helps break down this drug.) This could decrease Abstral's effectiveness. Your doctor is likely to closely monitor you for side effects if you're taking Abstral with any of the following:
  • barbiturates
  • carbamazepine
  • efavirenz
  • glucocorticoids
  • modafinil
  • nevirapine
  • oxcarbazepine
  • phenobarbital
  • phenytoin
  • pioglitazone
  • rifabutin
  • rifampin
  • St. John's wort
  • troglitazone (not available in the United States)

Continue Learning about Opiate Agonists

What should I know before taking opioids?
Donna Hill Howes, RNDonna Hill Howes, RN
Before prescribing an opioid for low back pain, your doctor should order a urine test to check for o...
More Answers
What are opioid medications?
Intermountain HealthcareIntermountain Healthcare
Opioid pain medication is a common type of prescription pain medication. It is also sometimes call...
More Answers
What are the risks of using opioid pain medication?
Devi E. Nampiaparampil, MDDevi E. Nampiaparampil, MD
The main effects and risks of using opioids include nausea and constipation, accidental overdose, an...
More Answers
What are alternatives to opioid pain medication?
Dr. Mehmet Oz, MDDr. Mehmet Oz, MD
Pain medicine is a slippery slope for most. Both doctors and patients should give serious considerat...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.