How is neuropeptide Y related to weight gain?

Marjorie Nolan Cohn
Nutrition & Dietetics

Low blood sugar levels stimulate the activity of the neurotransmitter Neuropeptide Y (NPY) in the hypothalamus, ramping up the desire for sweet and starchy food. When someone does not eat frequently enough, or is chronically dieting blood sugar can drop low which triggers NPY. When this happens on a regular basis NPY also starts to promote fat storage, or weight gain.

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