Do sumatriptan and naproxen sodium tablets interact with other medications?

When taking sumatriptan-naproxen tablets, do not take certain antidepressant medications called mono-amine oxidase inhibitors (MAOIs), serotonin norepinephrine reuptake inhibitors (SNRIs) or selective serotonin reuptake inhibitors (SSRIs). Tell your doctor if you have taken any medications that contain ergot.

Because naproxen is a non-steroidal anti-inflammatory drugs (NSAIDs), you should avoid taking aspirin or other NSAIDs. These, like naproxen, carry some risk of stomach bleeding and other serious gastrointestinal damage. These risks may be increased by blood-thinning medications (like warfarin), aspirin or steroids. Also, tell your doctor before taking sumatriptan and naproxen if you take any antidepressants, diuretics, cyclosporine, methotrexate, quinolones, serotonin 5-HT1 receptor agonists, beta-blockers, lithium or angiotensin-converting enzyme (ACE) inhibitors, because these medications can interact with sumatriptan and naproxen.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.