What are the side effects of hydrocodone and ibuprofen?

While taking hydrocodone-ibuprofen you may experience stomach upset, anxiety or dizziness. Stomach upset can include constipation, diarrhea, gas, heartburn, loss of appetite, nausea, stomach pain or vomiting. There is also a risk of developing serious ulcers or bleeding in the stomach if you take the medication too long, smoke or drink alcohol while taking the medication. You may also experience dry mouth, headaches, profuse sweating or nervousness, insomnia or weakness. If these side effects don't go away or get worse, contact your doctor. Signs of an allergic reaction may be signs of a medical emergency, such as hives or an itchy rash, swelling around the mouth or face or chest tightness and difficulty breathing. Call 911 for signs of an allergic reaction.

Also, let your doctor know right away if you experience any of the following side effects:

  • bloody, black or tarry stools or dark urine
  • blurry vision
  • unusually greater or lesser amounts of urination
  • chest pain
  • confusion
  • depression
  • fainting
  • irregular heartbeat
  • signs of an infection such as fever, chills or sore throat
  • mood swings
  • feeling weak along one side or numb in an arm or leg
  • skin that appears swollen, blistered or peeling
  • ringing in the ears
  • seizures
  • severe headaches or dizzy spells
  • severe stomach upset
  • shortness of breath or shallow breathing
  • stiff neck
  • gaining weight for no apparent reason and unusually quickly
  • swelling in the hands, legs or feet
  • unexplained bruising or bleeding
  • joint or muscle pain that is out of the ordinary
  • feelings of being unusually tired or weak
  • changes in vision or speaking
  • vomiting what look like coffee grounds
  • yellowing of the skin or eyes

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.