Who should not take ibuprofen and diphenhydramine?

You should not take ibuprofen-diphenhydramine if you have allergies to nonsteroidal anti-inflammatory pain relievers or antihistamines. As this drug causes drowsiness, you should not take it if you do not have time for a full night's sleep. This drug should not be used by children under 12 years of age. It also should not be used prior to heart surgery. If you have heart disease or hypertension, or have had a heart attack or stroke, you may not be able to take ibuprofen and diphenhydramine. Do not use this drug in combination with other drugs that contain diphenhydramine, even those that are topical (used only on the skin). Do not take this drug if you suffer from sleeplessness that is not accompanied by pain. Do not take this drug if you have taken a monoamine oxidase inhibitor (MAOI) in the past 14 days or if you are taking sodium oxybate (GHB). You should also not take this drug if you are pregnant or breastfeeding, unless directed to do so by your doctor.