Will piroxicam interact with other medicines I take?

Piroxicam could interact with a long a list of medicines, including digoxin, which is a medicine used for heart problems such as an irregular heartbeat; beta blockers, which may be taken for high blood pressure; certain antidepressants; and some antibiotics. Common over-the-counter medicines, such as aspirin and ibuprofen, can also interact with piroxicam. The effect on you depends on what drug is interacting with piroxicam. In some cases, piroxicam can worsen the side effects of the other drug, while in other cases, piroxicam can increase the amount of the other drug in your system, which could be dangerous. The best thing to do is to make sure your doctor has a list of all medicines you are taking, both prescription and over-the-counter. This way, they can let you know about possible interactions and, if possible, change or stop the medicines that are most likely to cause serious problems.