Who should not use sumatriptan and naproxen sodium tablets?

You should not use sumatriptan-naproxen if you are currently taking certain antidepressant medications, including monoamine oxidase inhibitors (MAOI) or selective serotonin reuptake inhibitors (SSRI). Women who are in the last trimester of pregnancy or breastfeeding should not use sumatriptan and naproxen.

Let your doctor know before using sumatriptan and naproxen if you have heart, kidney or liver disease, diabetes, history of stroke or other clotting problem, fluid retention, any blood disorders, high blood pressure, a blood vessel disease or condition or gastrointestinal conditions. If you smoke, are overweight, are in poor health, are past menopause, over 40, are on a low-sodium diet or have a history of alcohol abuse or dependency, tell your doctor as well. You should not take sumatriptan and naproxen to prevent migraines or for treatment of basilar or hemiplegic migraines or cluster headaches.