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How does mefenamic acid interact with other medications or food?

Mefenamic acid may interact with several other medications. Some drugs can increase the risk of specific side effects when they are combined with mefenamic acid. For example, blood thinners (such as warfarin) increase the risk of bleeding from the stomach or intestines; aspirin and other salicylates increase the risk of gastrointestinal problems including bleeding; and cyclosporine increases the risk of kidney damage. As well, mefenamic acid may decrease the effectiveness of other drugs, such as water pills (such as Lasix and thiazides) and angiotensin-converting enzyme (ACE) inhibitors. Mefenamic acid may also increase the amount of lithium and methotrexate in the body, thus increasing the risk of side effects from these drugs.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.