What should I know about sumatriptan and naproxen sodium tablets?

Sumatriptan-naproxen tablets, sold as Treximet, are prescribed to treat migraine headache pain. You should discuss with your doctor whether this medication is appropriate for you. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) which can cause serious health problems in some people. Do not take sumatriptan-naproxen if you have ever had any reaction to either drug or to aspirin or any other NSAID. Sumatriptan-naproxen is not meant to prevent a migraine or for treatment of basilar or hemiplegic migraines.

Do not take more than two tablets in 24 hours, and wait at least two hours between doses. Talk to your doctor about any other medications you're taking, because sumatriptan-naproxen can interact with many other drugs, including antidepressants. You should not use sumatriptan-naproxen if you are currently taking certain antidepressant medications, including monoamine oxidase inhibitors (MAOI) or selective serotonin reuptake inhibitors (SSRI).

Women who are in the last trimester of pregnancy or breastfeeding should not use sumatriptan-naproxen. Let your doctor know before using sumatriptan-naproxen if you have heart, kidney or liver disease, diabetes, history of stroke or other clotting problem, fluid retention, any blood disorders, high blood pressure, a blood vessel disease or condition or gastrointestinal conditions. If you smoke, are overweight, in poor health, are past menopause, are over 40, on a low-sodium diet or have a history of alcohol abuse or dependency, tell your doctor as well.

This drug has the risk of causing serious heart problems, stomach ulcers or bleeding, a possibly fatal condition called serotonin syndrome, kidney problems and dizziness. Talk to your doctor about these risks.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.