What should I know about oxaprozin before taking it?

Oxaprozin can raise your risk for potentially fatal ulcers in your intestines or stomach. Avoid drinking alcohol while you are taking oxaprozin, as this can raise your risk for stomach bleeding. Oxaprozin can increase your risk for stroke, heart attack, and other potentially deadly cardiovascular problems. If you are getting ready to have heart bypass surgery (or you have just had it), do not take oxaprozin. If you have an allergy to aspirin, oxaprozin, or other nonsteroidal anti-inflammatory drugs (NSAIDs), do not take this drug.

Talk to your doctor before taking oxaprozin if you smoke or have any drug allergies, asthma, nasal polyps, kidney or liver disease, high blood pressure, heart disease, congestive heart failure, or a history of stroke, blood clot, heart attack, bowel problems, diverticulosis, ulcers, or stomach bleeding. Oxaprozin should be avoided during pregnancy and while breast feeding as it could harm a fetus. While you are taking oxaprozin, you should ask your health care provider before taking any over-the-counter medications for pain, colds, or allergies. Certain over-the-counter drugs including aspirin, ibuprofen, ketoprofen, and naproxen act similarly to oxaprozin and can cause an overdose if taken with oxaprozin.

Oxaprozin can interact with prescription and over-the-counter drugs, including: aspirin, blood thinners such as warfarin (Coumadin), citalopram (Celexa), cyclosporine (Gengraf, Neoral, Sandimmune), duloxetine (Cymbalta, escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), lithium (Eskalith, Lithobold), NSAIDs such as diclofenac (Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone (Relafen), naproxen (Aleve, Naprosyn), and piroxicam (Feldene), paroxetine (Paxil, sertraline (Zoloft), steroids (such as prednisone) and venlafaxine (Effexor).

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.