The cause of neuralgia can't always be determined but it is often the result of a malfunctioning nerve. In some cases an out of place artery, a tumor or even tight muscles could be putting pressure on one of your nerves causing your pain. For others it may be the result of nerve damage caused by multiple sclerosis, shingles or an injury. There are several other possible causes as well, but they typically all have one thing in common. They involved the damage or aggravation of a specific nerve.