Who should not use dextromethorphan and promethazine?

Certain people should not use dextromethorphan and promethazine or should consult with a doctor before taking it. If you have asthma or other lung disease do not use this medication. Of course, anyone who is allergic to either dextromethorphan or promethazine should avoid the combination. Also, it may cause harmful reactions in people with certain medical conditions, including emphysema, chronic bronchitis, sleep apnea, high blood pressure, glaucoma, seizures, diabetes, liver, heart, or kidney disease, difficulty with breathing or urination, stomach problems, an overactive thyroid, or a bone marrow disorder. Similarly, dextromethorphan and promethazine may interact poorly in people taking certain medications, such as epinephrine, MAO inhibitors, stimulants like caffeine or ADHD medicine, drugs that make you sleepy, malaria drugs like halofantrine, Tourette's disorder medicine like pimozide, Parkinson's disease medications and other medications that treat cold and allergy symptoms. Do not use this medication if you have used MAO inhibitors within the last 2 weeks. Additionally, if you are pregnant or breastfeeding, you should alert your doctor, as dextromethorphan and promethazine may cause damage to your child's health. The FDA has categorized dextromethorphan-promethazine as pregnancy Category C. This is based on animal studies. Data on human pregnancy is not available. People who drink alcohol frequently cannot do so while on the medication. Those who are seeking a medicine to treat coughs caused by non-cold or allergy sources should not take dextromethorphan and promethazine.                                                                                       

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