Are there any risks in taking diphenhydramine?

There are generally no serious risks in taking diphenhydramine. However, in rare cases, allergic reactions to diphenhydramine have occurred. Symptoms of this include: hives, rash, closing of the throat and swelling of the face, lips or tongue. Also, certain medications should not be taken with diphenhydramine. These include monoamine oxidase inhibitors (MAOIs), such as phenelzine. Lower doses of diphenhydramine may be required for people with asthma, hyperthyroidism, stomach ulcers, enlarged prostate, hypertension or glaucoma. This medication may cause side effects in a breastfeeding baby; do not breastfeed while taking diphenhydramine.  

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