How does diphenhydramine interact with other medications?

Diphenhydramine should never be taken when a monoamine oxidase inhibitor (MAOI), such as isocarboxazid, tranylcypromine and phenelzine, has been taken within the previous 14 days. Other drugs that may interact with this medication include: alprazolam, diazepam, chlordiazepoxide, temazepam, triazolam, amitriptyline, doxepin, nortriptyline, fluoxetine, sertraline and paroxetine. Diphenhydramine also may interact with other medications that make you feel drowsy or sleepy. Alcohol may increase the dizziness or drowsiness side effect of diphenhydramine. In general, you should talk to your doctor before taking any new medications, vitamins, minerals or herbal products. Some other medications may contain an active ingredient that works similarly to diphenhydramine. Taking them at the same time as this medication could lead to an overdose of antihistamines.

Continue Learning about Nasal Agent

What medications interact with antihistamine nasal sprays?
Donna Hill Howes, RNDonna Hill Howes, RN
If you are taking thalidomide, orphenadrine, or an anticholinergic drug, olopatadine can lead to sid...
More Answers
Can decongestants relieve allergy symptoms?
If a stuffy, blocked-up nose is your primary allergy symptom, a decongestant may offer relief. These...
More Answers
What is the best over-the-counter antihistamine?
Sky Ridge Medical CenterSky Ridge Medical Center
When it comes to the best over-the-counter (OTC) antihistamines, I try hard to base my preferences n...
More Answers
What other medications do oral antihistamines interact with?
Donna Hill Howes, RNDonna Hill Howes, RN
If you are taking an opioid, antihistamines may not be good options for you. If you are taking a dr...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.