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What is the difference between OTC and prescription diphenhydramine?

Diphenhydramine, when administered as an injection, is available only as a prescription medication; it is available as a generic drug (diphenhydramine) or as the brand name Benadryl. You can also purchase diphenhydramine as both an oral prescription medication and an oral over-the-counter medication. It comes in both a generic form (diphenhydramine) or as the brand name Benadryl.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.