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What is the difference between OTC and prescription diphenhydramine?

Diphenhydramine, when administered as an injection, is available only as a prescription medication; it is available as a generic drug (diphenhydramine) or as the brand name Benadryl. You can also purchase diphenhydramine as both an oral prescription medication and an oral over-the-counter medication. It comes in both a generic form (diphenhydramine) or as the brand name Benadryl.

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