Does dextromethorphan and promethazine interact with other drugs?

Some medications might react poorly with dextromethorphan and promethazine and should be avoided or used with caution in combination with it. Problem medicines may include diet pills, blood pressure medicines like epinephrine, MAO inhibitors, stimulants like caffeine or ADHD medicine, drugs that make you sleepy, malaria drugs like halofantrine, Tourette's disorder medicine like pimozide, Parkinson's disease medications and other medications that treat cold, allergy and cough symptoms. Do not use this medication if you have used MAO inhibitors within the last 2 weeks. You should tell your doctor about all medicines, supplements, vitamins, and herbal remedies that you take before starting on dextromethorphan and promethazine. Also, avoid drinking alcohol while taking dextromethorphan and promethazine, as it can worsen some of the drug's side effects.