What are the possible side effects of naproxen/esomeprazole tablets?

Seek immediate medical attention if you have serious side effects of naproxen/esomeprazole delayed-release tablets, including black or bloody stools or blood in your urine or vomit; blurred vision; bone, muscle or joint pain; chest pain; change in urine amount; lightheadedness or fainting; cough, difficulty breathing or wheezing; fever or sore throat; fast or pounding heartbeat; flu-like symptoms; easy bruising or bleeding; difficulty or pain when swallowing; sudden or unexplained weight gain or swelling, especially of the hands or feet; and unusual bleeding or bruising.

Seek emergency medical attention if you experience symptoms of liver disease when taking this drug. Symptoms of liver disease include: persistent nausea or vomiting, dark yellow or brown urine, unusual or extreme weakness or tiredness or yellowing of the eyes or skin.

Go to the emergency room, call 911 if you have itching, swelling along with breathing difficulty or severe dizziness; these may be symptoms of a rare but serious allergic reaction. Call 911 if you experience chest pain, difficulty breathing or sudden slurred speech or weakness on one side of your body.

Naproxen/esomeprazole tablets may also cause side effects that do not require immediate medical attention. These less serious side effects include: diarrhea, constipation, dizziness, upset stomach, headaches, drowsiness, heartburn and stomach pain or gas. Your doctor may suggest ways to relieve these minor side effects.