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What is a denosumab injection?

Denosumab is the name of the active ingredient in two brand name products, Prolia and Xgeva. Prolia, denosumab 60 mg./ml., is used to treat osteoporosis in postmenopausal women who have a high risk of bone fracture. Prolia is administered by the doctor by injection every six months. Xgeva, denosumab 120 mg./1.7 ml., is used to prevent fractures in patients with solid tumors and bone metastases. Xgeva is administered once every four weeks. Denosumab is a monoclonal antibody that neutralizes the activity of molecules that are vital to the production of osteoclasts, which are responsible for breaking down bone. Fewer osteoclasts result in stronger bones and decreased risk of fracture.

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