What other drugs affect naproxen/esomeprazole delayed-release tablets?

Medications that may affect or be affected by naproxen/esomeprazole delayed-release tablets include: amphetamines; oral bisphosphonates; blood thinners like warfarin, enoxaparin and heparin; anti-platelet drugs like cilostazol and ticlopidine; methotrexate; medicines for blood pressure; SSRI/SNRI antidepressants, such as fluoxetine, sertraline and duloxetine; clopidogrel; cholestyramine; corticosteroids like prednisone; cidofovir; delavirdine; sucralfate; diuretics; seizure medications, such as fosphenytoin or phenytoin; sulfonamides; sulfonylureas; HIV drugs like atazanavir, nelfinavir and saquinavir; lithium; iron salts; pemetrexed; and probenecid.

You raise your risk of overdosing or experiencing side effects if you take naproxen/esomeprazole tablets with another proton pump inhibitor, another type of pain reliever or other NSAIDs like ibuprofen, naproxen or aspirin.

Naproxen/esomeprazole delayed-release tablets cause a decrease in stomach acid, which may affect your ability to absorb certain medications, including digoxin and azole antifungals like ketoconazole. The decrease in stomach acid may also make it more difficult for your body to absorb iron supplements.

If you drink more than three alcoholic beverages a day while on naproxen/esomeprazole delayed-release tablets, you may increase your risk of gastrointestinal problems, like stomach bleeding, ulcers, or holes in your stomach or intestines.

Other medications may also interact with naproxen/esomeprazole delayed-release tablets. Before taking this drug, give your doctor a list of medications you're currently on.

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