While taking leflunomide, you should avoid coming into contact with people who have a contagious illness, such as a cold or the flu. Taking leflunomide may decrease your ability to fight infection and you could catch an infection more easily. You should also not get vaccinated with a live vaccine while taking leflunomide without your doctor's approval. To avoid pregnancy while taking leflunomide, make sure that you are using effective birth control.
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