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Do naproxen and esomeprazole delayed-release tablets have interactions?

Taking naproxen and esomeprazole delayed-release tablets (Vimovo) with other proton pump inhibitors, another type of pain reliever, or other NSAIDs, such as ibuprofen, naproxen, aspirin, or acetaminophen, may cause an overdose or raise your chances of side effects.

Other medications that may affect or be affected by naproxen and esomeprazole delayed-release tablets include amphetamines; bisphosphonates taken by mouth; blood thinners, such as warfarin, enoxaparin, and heparin; anti-platelet drugs, such as cilostazol and ticlopidine; methotrexate; medicines for blood pressure; SSRI/SNRI antidepressants such as fluoxetine, sertraline, and duloxetine; clopidogrel; cholestyramine; corticosteroids, such as prednisone; cidofovir; delavirdine; sucralfate; diuretics; seizures medications, such as fosphenytoin or phenytoin; sulfonamides; sulfonylureas; HIV drugs, such as atazanavir, nelfinavir, and saquinavir; lithium; iron salts; pemetrexed; and probenecid.

Decrease in stomach acid may affect your absorption of some medications, including digoxin; azole antifungals, such as ketoconazole; and iron supplements.

Drinking more than three alcoholic beverages a day while on naproxen and esomeprazole delayed-release tablets may increase your risk of gastrointestinal problems, such as stomach bleeding, ulcers, or holes in your stomach or intestines. Other medications may also interact with naproxen and esomeprazole delayed-release tablets. Give your doctor a list of medications that you currently take before receiving this drug to ensure that none may affect it.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.