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What are the side effects of allopurinol?

Possible side effects of allopurinol may include acute gout attack, diarrhea, nausea and skin rash. If you start to experience even a slight skin rash while taking allopurinol, stop taking the medication and seek immediate medical care. Occasionally, a skin rash can be a symptom of a severe adverse reaction and prove quite serious or even fatal. The skin may itch or scale or flake off significantly, and as the rash worsens, chills, fever, joint pain or even jaundice may occur. Other symptoms of a severe adverse reaction include: painful urination, blood in the urine, irritation of the eyes, swelling of the lips or mouth, weight loss and change in appetite. Like all medications, allopurinol may cause an allergic reaction or unexpected side effects not previously described. If you experience any unanticipated reaction while taking allopurinol, contact your doctor immediately.

Allopurinol would be more likely to cause weight loss than weight gain. Patients report weight loss, nausea and loss of appetite with allopurinol.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.