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Which medications interact with cyclobenzaprine?

Donna Hill Howes, RN
Family Practitioner

If you are taking a 5-HT3 receptor antagonist, an antipsychotic drug, metoclopramide, cyclobenzaprine, an opioid, a serotonin reuptake inhibitor, or tramadol, cyclobenzaprine can lead to serious side effects and must be avoided.

If you are taking an inhaled anticholinergic drug, azelastine nasal spray, eluxadoline, orphenadrine, paraldehyde, potassium chloride in solid form, or thalidomide, cyclobenzaprine can lead to side effects and should be avoided.

If you are taking a central nervous system depressant, mirabegron, rufinamide, or topiramate, cyclobenzaprine may not be a good option for you.

If you take an MAO inhibitor, do not take cyclobenzaprine. You should not take cyclobenzaprine until at least 2 weeks after stopping MAO inhibitors.

If you take cyclobenzaprine, you should avoid alcohol and kava kava.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.