How should I take probenecid?

You may need to take probenecid for several months before you see an improvement in symptoms and a decline in gout attacks. Probenecid acts on the kidneys to help the body eliminate uric acid. You should take this medication, especially when you first begin treatment, with 10 to 12 full eight ounce glasses of water each day. This will help decrease your risk for kidney stones or other kidney problems. You should take probenecid exactly as directed by your doctor. Your doctor will typically recommend an initial dose of 250 mg. twice per day for the first week. This dose may be increased under your doctor's supervision, but typically it does not exceed four, 500 mg. tablets per day. If you are taking probenecid to improve the effectiveness of antibiotics, your dose will vary based on the indication. You may take probenecid with or without food or an antacid if it upsets your stomach. If you miss a dose, take the missed dose as soon as you remember it. If it is almost time for your next dose, skip the missed dose. Do not take a double dose to make up for a missed one. Do not abruptly discontinue use because doing so may increase your risk of a gout attack.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.