How long does it take to get pain relief from hyaluronic acid injections?

Dr. Vonda Wright, MD
Orthopedic Surgery
I never guarantee my patients that they're going to see any effect from hyaluronic acid (HA) injections until at least all three weekly shots are done. That said, people respond to these injections differently. Many of my patients say that after the first HA injection, their knees aren't as stiff or swollen. In other patients, it takes a while to feel pain relief. 
Keith Roach, MD
Internal Medicine
Hyaluronic acid injections, also called viscosupplement injections, don't offer immediate pain relief. They generally start working within two to four weeks and reach maximum benefit by eight weeks. Most people who respond well to this type of treatment for knee osteoarthritis find that the pain relief lasts for many months.

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