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How do the different brands of hyaluronic acid injections compare?

Grant Cooper, MD
Physical Medicine & Rehabilitation
There are currently several Food and Drug Administration (FDA) approved injectable preparations of hyaluronic acid: Synvisc, Hyalgan, Supartz, Orthovisc, and Euflexxa. Some are given as a series of five injections; others require only three. Whether or not you receive benefit from the first injection, the entire series is typically given because the effect can be cumulative.

Synvisc was the first hyaluronic acid preparation available in the United States, and many physicians use it or the next formulation that was approved, Hyalgan. The disadvantage of Synvisc is a slightly increased possibility of creating a reactive flare. None of the hyaluronic acid preparations has been proven superior to the others.
The Arthritis Handbook: Improve Your Health and Manage the Pain of Osteoarthritis (A DiaMedica Guide to Optimum Wellness)

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The Arthritis Handbook: Improve Your Health and Manage the Pain of Osteoarthritis (A DiaMedica Guide to Optimum Wellness)

According to conventional wisdom, arthritis pain is an inevitable part of aging. Not so, says Dr. Grant Cooper in this practical, accessible guide. For those who do develop osteoarthritic conditions,...

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.