Does Allopurinol interact with other medications or foods?

Allopurinol can interact with ingredients in some foods and medications. For example, do not take vitamin C supplements or consume excessive amounts of vitamin C, as this can interact with allopurinol and lead to kidney stone formation. The following medications can interact with allopurinol and alter its effectiveness: amoxicillin, ampicillin, anticoagulants, blood thinners, cancer chemotherapy drugs, chlorpropamide, cyclosporine, diabetes medications, diuretics, medications that suppress the immune system, mercaptopurine, probenecid, sulfinpyrazone, theophylline, thiazide diuretics and other gout medications. While taking allopurinol, you should also avoid purine-rich foods, such as anchovies, liver, kidneys and sardines. It is important to stay hydrated while taking allopurinol. You should drink at least 10 to 12 eight-ounce glasses of liquids per day. You may need to avoid alcohol while taking allopurinol since alcohol, especially beer and wine, can decrease its effectiveness.