Advertisement

What is GIFT15 treatment for multiple sclerosis (MS)?

An experimental treatment for multiple sclerosis (MS) completely reverses experimental allergic encephalomyelitis (EAE), the equivalent of MS in mice; the potential in humans has yet to be determined. Researchers at the Jewish General Hospital Lady Davis Institute for Medical Research and McGill University in Montreal developed the treatment that puts MS in remission by suppressing the immune response.

The new treatment, called GIFT15, is composed of two proteins, granulocyte macrophage-colony stimulating factor (GSM-CSF) and interleukin-15, fused together artificially in the lab. Normally the individual proteins act to stimulate the immune system, but in their fused form, the equation reverses itself.

The process began by taking normal B-cells from mice, purifying them in the lab, putting them in a Petri dish and sprinkling GIFT15 on them. Then they were given back intravenously to the mice that were ill with EAE. The disease in the mice completely disappeared. Researchers cautioned that the disease must be caught in its earliest stages, and clinical studies are needed to test the treatment's efficacy and safety in humans.

Continue Learning about Multiple Sclerosis Treatment

Can Alternative Therapies Help Manage Multiple Sclerosis?
Can Alternative Therapies Help Manage Multiple Sclerosis?
Many MS patients are looking for an extra advantage in managing symptoms or slowing disease progression. Watch neurologist Charles Smith, MD, explain ...
Read More
How is muscle weakness in multiple sclerosis (MS) treated?
Multiple Sclerosis FoundationMultiple Sclerosis Foundation
Muscle weakness can occur in multiple sclerosis (MS) as a result of slowing or loss of nerve impulse...
More Answers
Should I stop my multiple sclerosis (MS) treatment if it is not working?
Multiple Sclerosis FoundationMultiple Sclerosis Foundation
You may decide to stop using multiple sclerosis (MS) treatments altogether if they are not working f...
More Answers
Ask the Experts: Multiple Sclerosis Treatments
Ask the Experts: Multiple Sclerosis Treatments

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.