What tests assess disease progression in multiple sclerosis (MS)?

The following tools are used to assess disease progression in multiple sclerosis (MS):
  • Minimal record of disability (MRD) has two main functions. It is used to help plan and coordinate care for the individual with MS, and to provide a standardized means of recording repeated clinical evaluations for research purposes. The MRD consists of five parts: demographic information, the Environmental Status Scale, the Disability Status Scale, the
  • Incapacity Status Scale, and the Neurological Functional Systems.
  • Kurtzke expanded disability status scale (EDSS) ranges from one to ten. A person with EDSS score of five or lower can walk independently, whereas a person with a higher score requires some assistance with walking or the use of a wheelchair. Although EDSS is a useful measuring tool in many clinical trials, it should not be interpreted as a true measure of disability because it does not consider upper extremity function, fatigue, or cognitive function
  • Scripps Neurological Scale is used to assess the severity of clinical exacerbations (or relapses) in clinical trials.
  • Magnetic resonance imaging (MRI) scans detect new lesions as well as changes in existing lesions that are clinically undetectable, or asymptomatic. MS is a dynamic disease in which there can be a significant accumulation of lesions, even in clinically stable patients. Yet 5 percent of people with MS show no evidence of the disease on MRI.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.