What tests assess disease progression in multiple sclerosis (MS)?

The following tools are used to assess disease progression in multiple sclerosis (MS):
  • Minimal record of disability (MRD) has two main functions. It is used to help plan and coordinate care for the individual with MS, and to provide a standardized means of recording repeated clinical evaluations for research purposes. The MRD consists of five parts: demographic information, the Environmental Status Scale, the Disability Status Scale, the
  • Incapacity Status Scale, and the Neurological Functional Systems.
  • Kurtzke expanded disability status scale (EDSS) ranges from one to ten. A person with EDSS score of five or lower can walk independently, whereas a person with a higher score requires some assistance with walking or the use of a wheelchair. Although EDSS is a useful measuring tool in many clinical trials, it should not be interpreted as a true measure of disability because it does not consider upper extremity function, fatigue, or cognitive function
  • Scripps Neurological Scale is used to assess the severity of clinical exacerbations (or relapses) in clinical trials.
  • Magnetic resonance imaging (MRI) scans detect new lesions as well as changes in existing lesions that are clinically undetectable, or asymptomatic. MS is a dynamic disease in which there can be a significant accumulation of lesions, even in clinically stable patients. Yet 5 percent of people with MS show no evidence of the disease on MRI.

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