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How do ergotamines interact with other medications?

Donna Hill Howes, RN
Family Practitioner

If you are taking an azole antifungal, a macrolide antibiotic, an NNRTI, or a protease inhibitor, you should not take ergotamines.

If you are taking a beta blocker, ergotamines may not be good options for you.

If you are taking a strong CYP3A4 inhibitor (such as an azole antifungal, macrolide antibiotic, protease inhibitor, or NNRTI), you should not take ergotamines. If you are taking a less potent CYP3A4 inhibitor, ergotamines may not be good options for you.

If you are taking enzalutamide or nitroglycerin, ergotamines can lead to side effects and should be avoided.

If you are taking a sympathomimetic drug, ergotamines can lead to serious side effects.

You should not take an ergotamine within 24 hours of taking a triptan.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.