Does metformin interact with other medications?

Some of the medications that interact with metformin include:

  • digoxin
  • cimetidine
  • furosemide
  • nifedipine
  • amiloride
  • ranitidine
  • triamterene
  • morphine
  • quinidine
  • vancomycin
  • trimethoprim
  • procainamide

Taking metformin with other drugs that lower blood sugar can raise your risk of hypoglycemia. These  include:

  • glipizide
  • glyburide
  • glimepiride
  • repraglinide
  • netaglinide
  • sitagliptin
  • saxagliptin
  • probencid
  • beta-blockers
  • sulfa drugs
  • salicylates
  • monoamine oxidase inhibitors
  • certain nonsteroidal anti-inflammatory drugs (NSAIDs)

Alcohol can also lower your blood sugar and increase your chance of developing lactic acidosis. In addition, your risk of hyperglycemia (high blood sugar) may be increased if you take metformin with other medications that increase blood sugar levels. These include:

  • thyroid medications
  • steroids
  • isoniazid
  • diet pills
  • seizure medications
  • birth control pills
  • diuretics
  • phenothiazines

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.