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Who is at risk for mucopolysaccharidoses (MPS)?

It is estimated that one in every 25,000 babies born in the United States will have some form of mucopolysaccharidoses (MPS). Since this is an autosomal recessive disorder, only individuals inheriting the defective gene from both parents are affected. (The exception is MPS II, or Hunter syndrome, in which the mother alone passes the defective gene to a son.) When both parents have the defective gene, each pregnancy carries with it a one in four chance that the child will be affected. The parents and siblings of an affected child may have no sign of the disorder. Unaffected siblings and select relatives of a child with one of the mucopolysaccharidoses may carry the recessive gene and could pass it to their own children.

In general, the following factors may increase the chance of getting or passing on a genetic disease:

A family history of a genetic disease. Parents who are closely related or part of a distinct ethnic or geographic circle. Parents who do not show disease symptoms, but carry a disease gene.

MPS are classified as lysosomal storage diseases. These are conditions in which large numbers of molecules that are normally broken down or degraded into smaller pieces by intracellular units called lysosomes accumulate in harmful amounts in the body's cells and tissues, particularly in the lysosomes.

This answer is based on source information from the National Institute of Neurological Disorders and Stroke.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.