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What causes androgen insensitivity syndrome?

Androgen insensitivity syndrome (AIS) is caused by certain genetic mutations. The genetic mutation that causes AIS may be inherited, or it may occur spontaneously even if the parents don't have the mutation. Normally, a gene called the AR gene produces proteins that allow cells to respond to male sex hormones called androgens. When the AR gene is mutated, these proteins don't work and cells can't respond to androgens correctly. In complete androgen insensitivity syndrome, cells don't respond to these hormones at all. In partial androgen insensitivity syndrome, cells may just be less responsive than normal to androgens.

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