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Does androgen insensitivity syndrome run in families?

Androgen insensitivity syndrome, or AIS, can run in families. AIS is caused by mutations on the X chromosome that prevent the body from being able to respond to male sex hormones. In order for these mutations to cause AIS, a female must have two mutated X chromosomes and a male will have one mutated X chromosome. If a female has one mutated X chromosome, she does not have AIS but she is a carrier. In those cases, she can pass that mutation on to her child, who may develop the disease. This mutation is inherited this way the majority of the time; less often, it occurs randomly out of nowhere.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.