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Why do I need to go into withdrawal before being prescribed suboxone?

In 2002, the U.S. Food and Drug Administration (FDA) approved buprenorphine (suboxone) for the treatment of opioid addiction. It is a partial agonist of the μ-opioid receptor, but it has a higher binding strength than full opioids. What this means is that if you had heroin or methadone in your system, the suboxone would kick off the full agonists and attach itself and give only partial activation. Therefore, it puts a person in severe withdrawal. That’s why it’s important to make sure the person is in a state of withdrawal before starting suboxone. Even if it’s mild withdrawal, any withdrawal is required, or the person will go into a more severe withdrawal state.

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